Influenza Controlled Human Infection Model (“FluCHIM”)

Influenza, also known as the flu, is a contagious illness that affects the respiratory system (lungs and throat). Each year, it causes millions of people to miss school or work and puts extra pressure on hospitals and healthcare providers.

The flu virus can change and spread quickly. To better respond to new strains or stop future pandemics, we first need to know more about how the flu infects people and how the body fights back.

One way to study the flu very closely is with a Controlled Human Infection Model (CHIM). These studies expose healthy adult volunteers to a virus (like influenza) or a bacteria (like pertussis) in a safe and controlled setting.

This study will help to create a model, or a specific way of doing research, that will help future flu vaccines to be tested quickly while keeping the highest quality of research standards.

To learn more about CHIMs, also sometimes called challenge studies, take a look at our blog series. In this series, we explain what CHIM and challenge studies are, how and why they are done, and how we keep participants safe and comfortable during their stay.

Most people who get influenza (the flu) only feel mildly ill. However, for some, especially those under 6 and over 65, the flu can be severe.

Flu symptoms usually start 1 to 4 days after exposure to the virus and usually include fever, cough, and muscle aches. Other common symptoms include chills, tiredness, headache, sore throat, loss of appetite, and a runny or stuffy nose.

The best way to prevent or stop the spread of the flu is to get vaccinated. Unlike some vaccines, which are only given once, flu vaccines need to be given yearly. The National Advisory Committee on Immunization (NACI) recommends that all people in Canada aged 6 months and older get a seasonal flu vaccine.

Sources: Flu (influenza): For health professionals – Canada.ca

Participants must be 18 – 45 and in good health.

Other criteria may exclude you from this study. A team member will go over these criteria during your first conversation.

Interested in participating? Here are a few things you should know:

• You will be exposed to the flu virus under expert medical care and may become mildly ill.
• You will spend an estimated 7 – 11 days and nights in a specialized hospital room.
• Your vitals and samples will be collected daily during the hospital stay.
• You will be cared for by experienced staff who are dedicated to supporting your comfort and wellness. You are welcome to fill your free time as you choose between study tasks.

For more information on the Challenge Unit and what it’s like to participate, visit challengeunit.ca

This study is funded by the Canadian Institutes of Health Research (CIHR)
Operating Grant: Clinical Trials Projects (RN#531438).
Project name: CTF2024-FluCHIM
IWK REB Project Number: 1031787