Immune Profiling and Biospecimen Collection in Acute Epstein-Barr Virus Infection

In this study, we want to see how the immune system responds in teens and young adults who naturally become positive for Epstein-Barr Virus (EBV) during the study period. This could support development of future protections like vaccines. 

Epstein-Barr virus (EBV), also known as human herpesvirus-4, is one of the most common viruses in the world, affecting more than 90% of the global adult population. Most people get EBV as kids, and don’t get any symptoms. But if you are infected as a teen or older, it can lead to infectious mononucleosis (also known as mono) and other more serious illnesses.  

After infection, the virus can remain dormant in the body and can reactivate later in your life. If it does, you may not have any symptoms but could still spread the virus to others.  

There are not currently any licensed vaccines or antiviral therapies for EBV, despite the serious health impact it can have on teens and young adults. Better understanding of EBV infections is important to help researchers work towards these protections.  

This study is looking for participants who: 

• Are between the ages of 16-25 years; 

• Are not immunocompromised; 

• Are not pregnant or planning on becoming pregnant; 

• Have no known history of having infectious mononucleosis (also known as mono); 

• Can travel to Halifax, NS for multiple visits spread out over a period of 4-10 months; and; 
• Are willing to give blood and saliva samples  

What to expect if you sign up for this study: 

• Screening to check if you can participate (this includes a pregnancy test and other health evaluations) 

• A blood sample to see if you are negative for Epstein-Barr Virus (EBV) 

• If you test negative for EBV, multiple scheduled clinic visits for up to 4 months which will involve blood and saliva samples (spit samples) 

• If you naturally become positive for EBV during the study, you will be asked to attend more clinic visits so we can monitor your illness and to give blood and saliva samples during your infection. 

• Participants will be financially compensated for their time and participation 

A member of the study team will go over all the study details with you to make sure you understand all the details and possible risks before agreeing to take part.