Current Studies

GRACE (investiGational Rsv mAternal vaCcinE)

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Participants needed: Women aged 18-49

Participants needed: Women aged 18-49

View PosterThe Journey Begins Here (.pdf)

What is RSV?

Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants. RSV is a common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age.

Like the flu, RSV has season patterns, but unlike the flu there are no currently approved vaccines for the virus.

Purpose

  • Find out if the new vaccine given to pregnant women prevents RSV disease in their babies,
  • Make sure the new vaccine is safe for pregnant women and their babies,
  • Find out how well the vaccine can boost antibodies to RSV in pregnant women,
  • Find out how well the boosted RSV antibodies are passed to the babies,
  • Measure how long the RSV antibodies stay in the babies’ blood, and
  • Find out if pregnant women who receive the RSV vaccine visit a health care provider less often for cold-like illnesses, and if RSV caused the illnesses.

Eligibility

You can participate in this study if:

  • 18 to 49 years of age
  • Between 24 to 34 weeks pregnant at the time of your vaccination
  • Experiencing an uncomplicated pregnancy and are in good health
  • Willing to consent to have your baby take part in the follow-up study

Your Involvement

If you choose to take part, you will be in the study from the time you sign this form until six months after delivery. Your baby will be in the study from birth until their first birthday.

Participation in the study involves up to 8 scheduled study visits for you and your baby. There are 5 visits for you over a 6 month period and 5 visits for your baby over a 12 month period. Some of
the visits are combined. You will also be contacted by the study staff weekly or monthly (depending on the season) by a phone call or email. The visits will occur at the Canadian Center for Vaccinology (CCfV) located at the IWK Health Centre. We estimate the total time commitment to participate in the study will be approximately 8-10 hours for you and your baby

NOTE: We ask that you review the information and consent form before volunteering for this study. After review, please contact Angi Perreault. The information and consent form will be reviewed with you during your first site visit before signing.

Contact Angi Perreault

Phone 902-470-3741

Email angela.perreault@iwk.nshealth.ca

Find out more about this study

Please fill out the form below and we will be in touch shortly.